Do you ever wonder how your physician chooses an appropriate medication for you? Do you feel overwhelmed from the sheer number of available medications? These tips will help you understand the choices that are available. In subsequent articles, there will be more information about each class of medication.
While there are hundreds of medications and combinations of medications available, there are seven different classes of medication. Every class works in a different way. Your physician utilizes his knowledge about you as well as your specific type of diabetes to first evaluate if you need any medication, and if so , which class to use. He then chooses a medication from that course. If you require medication from several class he may choose to prescribe several medication or a combination pill that has two or more medications contained in it. This article will provide a brief overview of the classes of medications and how they work.
1 . ) The oldest class of medication is the sulfonylureas. Till the mid-1990s, this was the only class associated with oral medications available. Your body should be able to produce insulin in order for these types of to be beneficial, as they work simply by stimulating the beta cells from the pancreas to secrete insulin. A few examples of the first generation of these medicines are: Tolbutamide (orinase), Tolinase (tolazamide), and Diabinese (chlorpropamide). Some of the second generation medications are: Glipizide (glucatrol), extended release Glipizide (glucatrol XL), Glyburide (Micronase, Diabeta), Glynase (micronized glyburide), and Glimepiride. These medications are distinguished by how long they will last in the body, and whether they are cleared by the kidney or the liver organ. There are two other drugs on this class: Prandin and Starlix, which may be used before meals because they last for a very short time.
2 . ) The biguanide class has just one particular medication, called Metformin. Other names are Fortamet, Glucophage, Gluymetza, and Riomet. This medication works by reducing glucose production in the liver, and in addition it causes a small increase in glucose subscriber base by skeletal muscle. If there are no contraindications, the American Diabetes Association as well as the American college of clinical endocrinologists recommends using this medicine first.
3. ) In the mid-1990s, the Thiazolidinedione class of medicines (also known as glitizones or TZDs) was developed. Their primary mechanism of action is to increase insulin awareness, which leads to more glucose getting taken up by skeletal muscle. Three medications were developed.
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The first, Rezulin (troglitazone), was taken off the market because it was suggested to cause liver organ problems. The second, Avandia (rosiglitazone), had been withdrawn from the market in Europe but was allowed under selling limitations in the US because of an increase in cardiovascular events. The third medication, Actos (pioglitazone) had sales suspended in France and Germany because a study suggested it may increase the risk of bladder cancer.
4. ) Drugs that affect the incretin system are divided into two subclasses:
a. The first division is composed of injectable drugs which usually mimic the effect of natural incretins produced by the body. Medications in this course include Byetta (exenetide), Bydureon (long acting exenatide) Victoza (liraglutide), and Symlin. They work by improving insulin secretion in response to glucose (sugar), decreasing the rate at which the liver organ puts out glucose, decreasing appetite, through slowing the rate the stomach empties. These medications have become quite popular simply because they can help with weight loss, and have an extremely reduced incidence of hypoglycemia. However , these types of medications have been in the news because they have been associated with pancreatitis, and may lead to a small increase in medullary thyroid cancer.
n. The oral medications in this class work by blocking the enzyme which breaks down the incretins. While the level of natural incretins increases somewhat, these drugs are not as effective as the injectable ones. Medications in this class include Januvia (sitagliptin), Onglyza (saxagliptin), and Tradjenta. They are becoming observed to watch out for complications similar to the injectable medications. They very rarely result in hypoglycemia and do not cause weight gain. They are all being evaluated for a potential cancer risk.
5. ) There are 3 Alpha Glucosidase Inhibitors: Acarbose (Precose), Miglitol (Glyset), and Voglibose. These types of work by preventing digestion associated with carbohydrates in the intestine. By stopping carbohydrates from being converted into simple sugars and absorbed into the blood stream from the intestine, this class associated with medications can help keep the blood sugar from rising after meals.
6. ) The newest class of medications may be the SGLT2 inhibitors, which block absorption of glucose by the kidney. Simply by increasing the amount of glucose lost through the urine, and decreasing the amount of sugars absorbed back into the blood stream, blood sugar levels may be decreased. Because none of these medications has been approved by the FOOD AND DRUG ADMINISTRATION, the names of the medications are omitted from this article.
7. ) Insulin must be used for people with type I Diabetes and is often needed for those with type 2 Diabetes. There are many types and delivery systems which will be discussed consequently.
With a thorough understanding of your specific kind of diabetes, your physician can wade by means of all the options to select the best complement for you. More detailed information about each drug class will be presented in following articles here, and on my web site, diabeticsurvivalkit. com. Please feel free to go to at any time for information about medications, food preparation videos featuring diabetic meal and dessert recipes, and current information articles.
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